The prolonged use of ecstasy might induce dependence, characterized by tolerance and hangover. Ecstasy users showed a high risk of developing psychopathological disturbances. There is debate on whether recreational doses of ecstasy cause permanent damage to human serotonergic neurons. Acutely, ecstasy increases the release of serotonin and decreases its reuptake, leading to hypertension, hyperthermia, trismus, and vomiting. The drug is used by the oral route for long hours during crowded dance parties. Therefore, health care providers need to promptly recognize the symptoms of systemic intoxication in order to initiate early treatment. However, there are many reports of adverse effects, including acute intoxication, abuse potential, and possible neurotoxic effects. Youngsters are increasingly using 3,4 methylenedioxymethamphetamine, known as ecstasy, because it is wrongly believed that it does not induce harm.
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